loading...| Preferred Name | EGFR non-clathrin mediated endocytosis | |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1045 phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009871 |
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 At higher concentrations of ligand, a substantial fraction of the receptor (>50%) is endocytosed through a clathrin independent, lipid-raft-dependent route as the receptor becomes Y1045 phosphorylated and ubiquitnated. Eps15 and Epsin are found in caveolae. Eps15 and Epsin are immunoprecipated with the EGF receptor. Non-clathrin internalization of ubiquitinated EGFR depends on its interaction with proteins harbouring the UIM Ub-interacting motif, as shown through the ablation of three Ub-interacting motif-containing proteins, Eps15, Eps15R and Epsin. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| definition source |
Reactome, http://www.reactome.org Pubmed15701692 Pubmed12072436 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0012575 http://purl.obolibrary.org/obo/HINO_0012653 http://purl.obolibrary.org/obo/UniProt_Q9Y6I3 |
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| label |
EGFR non-clathrin mediated endocytosis |
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| prefixIRI |
HINO:0009871 |
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| prefLabel |
EGFR non-clathrin mediated endocytosis |
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| seeAlso |
ReactomeREACT_12527 Reactome Database ID Release 43183072 |
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