loading...| Preferred Name | Sprouty sequesters CBL away from active EGFR | |
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Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Sprouty can constitutively interact with two SH3 domains of CIN85 whereas the third SH3 domain of CIN85 can still associate with CBL on cell activation with EGF. This allows Sprouty to block CIN85-mediated clustering of CBL molecules, stablization of CBL-EGFR interactions and efficient ubiquitination and down-regulation of EGFR. |
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http://purl.obolibrary.org/obo/HINO_0009865 |
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| comment |
Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Sprouty can constitutively interact with two SH3 domains of CIN85 whereas the third SH3 domain of CIN85 can still associate with CBL on cell activation with EGF. This allows Sprouty to block CIN85-mediated clustering of CBL molecules, stablization of CBL-EGFR interactions and efficient ubiquitination and down-regulation of EGFR. |
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| definition source |
Pubmed15962011 Reactome, http://www.reactome.org |
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| label |
Sprouty sequesters CBL away from active EGFR |
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| prefixIRI |
HINO:0009865 |
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| prefLabel |
Sprouty sequesters CBL away from active EGFR |
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ReactomeREACT_12387 Reactome Database ID Release 43182990 |
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