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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009832
http://purl.obolibrary.org/obo/HINO_0009832
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|---|---|
| Preferred Name | Ubiquitination of stimulated EGFR (CBL) |
| Definitions |
has a Stoichiometric coefficient of 2
Edited: Orlic-Milacic, Marija, 2011-08-25
Reviewed: Heldin, CH, 2008-02-12 09:44:02
Authored: Castagnoli, L, 2006-10-10 13:09:34
CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Ubiquitination of stimulated EGFR (CBL)
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|---|---|
| comment |
has a Stoichiometric coefficient of 2
Edited: Orlic-Milacic, Marija, 2011-08-25
Reviewed: Heldin, CH, 2008-02-12 09:44:02
Authored: Castagnoli, L, 2006-10-10 13:09:34
CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain.
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| prefLabel |
Ubiquitination of stimulated EGFR (CBL)
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| definition source |
Pubmed10514377
Reactome, http://www.reactome.org
Pubmed15021893
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| prefixIRI |
HINO:0009832
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| seeAlso |
Reactome Database ID Release 43182993
EC Number: 6.3.2.19
ReactomeREACT_12515
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| subClassOf | |
| type | |
| has input | |
| has output |
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