loading...| Preferred Name | CBL binds and ubiquitinates phosphorylated Sprouty | |
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Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Sprouty is ubiquitinated by CBL in an EGF-dependent manner. EGF stimulation induces the tyrosine phosphorylation of Sprouty, which in turn enhances the interaction of Sprouty with CBL.The CBL-mediated ubiquitination of Sprouty targets the protein for degradation by the 26S proteosome. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009829 |
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| comment |
Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Sprouty is ubiquitinated by CBL in an EGF-dependent manner. EGF stimulation induces the tyrosine phosphorylation of Sprouty, which in turn enhances the interaction of Sprouty with CBL.The CBL-mediated ubiquitination of Sprouty targets the protein for degradation by the 26S proteosome. |
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| definition source |
Reactome, http://www.reactome.org Pubmed12593796 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0012575 |
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| label |
CBL binds and ubiquitinates phosphorylated Sprouty |
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| prefixIRI |
HINO:0009829 |
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CBL binds and ubiquitinates phosphorylated Sprouty |
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| seeAlso |
ReactomeREACT_12432 EC Number: 6.3.2.19 Reactome Database ID Release 43183089 |
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