loading...| Preferred Name | Sprouty lures cytosolic CBL away from EGFR | |
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Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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http://purl.obolibrary.org/obo/HINO_0009826 |
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Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| definition source |
Pubmed12234920 Reactome, http://www.reactome.org Pubmed12593795 |
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| label |
Sprouty lures cytosolic CBL away from EGFR |
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| prefixIRI |
HINO:0009826 |
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Sprouty lures cytosolic CBL away from EGFR |
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ReactomeREACT_12500 Reactome Database ID Release 43182988 |
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