loading...| Preferred Name | Ubiquitination of stimulated EGFR (CBL:GRB2) | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain. |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0009825 |
|
| comment |
has a Stoichiometric coefficient of 2 Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 CBL down-regulates receptor tyrosine kinases by conjugating ubiquitin to them. This leads to receptor internalization and degradation. The ubiquitin protein ligase activity of CBL (abbreviated as E3 activity) is mediated by its RING finger domain. |
|
| definition source |
Pubmed10514377 Reactome, http://www.reactome.org Pubmed15021893 |
|
| has input | ||
| has output | ||
| label |
Ubiquitination of stimulated EGFR (CBL:GRB2) |
|
| prefixIRI |
HINO:0009825 |
|
| prefLabel |
Ubiquitination of stimulated EGFR (CBL:GRB2) |
|
| seeAlso |
ReactomeREACT_12562 Reactome Database ID Release 43183036 EC Number: 6.3.2.19 |
|
| subClassOf |