loading...| Preferred Name | Sprouty lures membrane-bound CBL away from EGFR | |
| Synonyms |
|
|
| Definitions |
Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0009815 |
|
| comment |
Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
|
| definition source |
Pubmed12234920 Reactome, http://www.reactome.org Pubmed12593795 |
|
| has input | ||
| has output | ||
| label |
Sprouty lures membrane-bound CBL away from EGFR |
|
| prefixIRI |
HINO:0009815 |
|
| prefLabel |
Sprouty lures membrane-bound CBL away from EGFR |
|
| seeAlso |
ReactomeREACT_12441 Reactome Database ID Release 43183035 |
|
| subClassOf |