Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants
Synonyms
Definitions

Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 The 110 kDa catalytic subunit of PI3K (PIK3CA) binds to the 85 kDa regulatory subunit of PI3K (PIK3R1) to create the active PI3K. EGFR cancer mutants are assumed to mediate the assembly of active PI3K in a manner similar to wild-type EGFR. Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15

ID

http://purl.obolibrary.org/obo/HINO_0009800

comment

Edited: Wu, G, 2011-11-07

Authored: Orlic-Milacic, M, 2011-11-04

Edited: D'Eustachio, P, 2011-11-07

The 110 kDa catalytic subunit of PI3K (PIK3CA) binds to the 85 kDa regulatory subunit of PI3K (PIK3R1) to create the active PI3K. EGFR cancer mutants are assumed to mediate the assembly of active PI3K in a manner similar to wild-type EGFR.

Edited: Matthews, L, 2011-11-07

Reviewed: Greulich, H, 2011-11-15

Reviewed: Savas, S, 2011-11-15

definition source

Reactome, http://www.reactome.org

Pubmed15284455

has input

http://purl.obolibrary.org/obo/UniProt_P42336

http://purl.obolibrary.org/obo/HINO_0012517

has output

http://purl.obolibrary.org/obo/HINO_0012511

label

Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants

prefixIRI

HINO:0009800

prefLabel

Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFR mutants

seeAlso

ReactomeREACT_116004

Reactome Database ID Release 431226012

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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