Edited: Wu, G, 2011-11-07 Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFR cancer mutants and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFR cancer mutants, other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFR cancer mutants. Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15

http://purl.obolibrary.org/obo/HINO_0009783

Edited: Wu, G, 2011-11-07

Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFR cancer mutants and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFR cancer mutants, other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFR cancer mutants.

Authored: Orlic-Milacic, M, 2011-11-04

Edited: D'Eustachio, P, 2011-11-07

Edited: Matthews, L, 2011-11-07

Reviewed: Greulich, H, 2011-11-15

Reviewed: Savas, S, 2011-11-15

Reactome, http://www.reactome.org

Pubmed15284455

http://purl.obolibrary.org/obo/HINO_0012505

http://purl.obolibrary.org/obo/HINO_0004980

http://purl.obolibrary.org/obo/UniProt_P19174

Dissociation of phosphorylated PLC-gamma 1 from p-EGFR mutants

HINO:0009783

Dissociation of phosphorylated PLC-gamma 1 from p-EGFR mutants

ReactomeREACT_115903

Reactome Database ID Release 431247842

http://purl.obolibrary.org/obo/INO_0000040