loading...| Preferred Name | Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL | |
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has a Stoichiometric coefficient of 2 Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Gillespie, ME, 2011-11-07 Phosphorylated CBL does not ubiquitinate EGFR kinase domain mutants efficiently, which enables mutant proteins to escape degradation. There are indications that phosphorylated CBL shows decreased affinity for EGFR kinase domain mutants compared to wild-type EGFR proteins, and quickly dissociates, before ubiquitination is completed. This decreased affinity may be due to altered structure of EGFR kinase domain mutants or to the presence of the chaperone protein HSP90 in complex with the mutant protein. Weaker afinity for phosphorylated CBL was directly demonstrated for EGFR L858R mutant (Yang et al. 2006), and poor ubiquitination inspite of CBL binding was shown for EGFR L858R and EGFR E746_A750del mutants (Yang et al. 2006, Padron et al. 2007). Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 |
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http://purl.obolibrary.org/obo/HINO_0009782 |
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has a Stoichiometric coefficient of 2 Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Gillespie, ME, 2011-11-07 Phosphorylated CBL does not ubiquitinate EGFR kinase domain mutants efficiently, which enables mutant proteins to escape degradation. There are indications that phosphorylated CBL shows decreased affinity for EGFR kinase domain mutants compared to wild-type EGFR proteins, and quickly dissociates, before ubiquitination is completed. This decreased affinity may be due to altered structure of EGFR kinase domain mutants or to the presence of the chaperone protein HSP90 in complex with the mutant protein. Weaker afinity for phosphorylated CBL was directly demonstrated for EGFR L858R mutant (Yang et al. 2006), and poor ubiquitination inspite of CBL binding was shown for EGFR L858R and EGFR E746_A750del mutants (Yang et al. 2006, Padron et al. 2007). Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed16849543 Pubmed17699773 |
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Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL |
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HINO:0009782 |
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Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL |
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Reactome Database ID Release 431225956 ReactomeREACT_115732 EC Number: 6.3.2.19 |
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