Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
Synonyms
Definitions

has a Stoichiometric coefficient of 2 Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Edited: Gillespie, ME, 2011-11-07 Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 EGFR L858R mutant was shown to directly phosphorylate CBL on tyrosine residue Y371. Other EGFR cancer mutants with phosphorylation of tyrosine Y1045 (Y1069) are assumed to bind and phosphorylate CBL in a manner similar to the wild-type EGFR.

ID

http://purl.obolibrary.org/obo/HINO_0009781

comment

has a Stoichiometric coefficient of 2

Edited: Wu, G, 2011-11-07

Authored: Orlic-Milacic, M, 2011-11-04

Edited: D'Eustachio, P, 2011-11-07

Edited: Gillespie, ME, 2011-11-07

Edited: Matthews, L, 2011-11-07

Reviewed: Greulich, H, 2011-11-15

Reviewed: Savas, S, 2011-11-15

EGFR L858R mutant was shown to directly phosphorylate CBL on tyrosine residue Y371. Other EGFR cancer mutants with phosphorylation of tyrosine Y1045 (Y1069) are assumed to bind and phosphorylate CBL in a manner similar to the wild-type EGFR.

definition source

Reactome, http://www.reactome.org

Pubmed16849543

has input

http://purl.obolibrary.org/obo/HINO_0012489

http://purl.obolibrary.org/obo/CHEBI_15422

has output

http://purl.obolibrary.org/obo/HINO_0012488

http://purl.obolibrary.org/obo/CHEBI_16761

label

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants

prefixIRI

HINO:0009781

prefLabel

Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants

seeAlso

ReactomeREACT_115796

EC Number: 2.7.10

Reactome Database ID Release 431225960

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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