loading...| Preferred Name | Trans-autophosphorylation of EGFRvIII mutant dimers | |
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Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 has a Stoichiometric coefficient of 10 Upon dimerization, EGFRvIII mutants trans-autophosphorylate on tyrosine residues Y992, Y1068, Y0186, Y1143 and Y1173 while the tyrosine residue Y1045, a docking site for CBL, remains either unphosphorylated or hypophosphorylated, allowing EGFRvIII to activate downstream signaling cascades while escaping downregulation. Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 |
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http://purl.obolibrary.org/obo/HINO_0009777 |
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Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 has a Stoichiometric coefficient of 10 Upon dimerization, EGFRvIII mutants trans-autophosphorylate on tyrosine residues Y992, Y1068, Y0186, Y1143 and Y1173 while the tyrosine residue Y1045, a docking site for CBL, remains either unphosphorylated or hypophosphorylated, allowing EGFRvIII to activate downstream signaling cascades while escaping downregulation. Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15 |
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Pubmed17646646 Reactome, http://www.reactome.org Pubmed16969069 |
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Trans-autophosphorylation of EGFRvIII mutant dimers |
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HINO:0009777 |
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Trans-autophosphorylation of EGFRvIII mutant dimers |
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ReactomeREACT_115610 Reactome Database ID Release 431248655 EC Number: 2.7.10 |
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