Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex
Synonyms
Definitions

Edited: Wu, G, 2011-11-07 Authored: Orlic-Milacic, M, 2011-11-04 Edited: D'Eustachio, P, 2011-11-07 Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphorylated dimers of EGFR cancer mutants has not been directly tested, but is assumed to happen in the same way it happens with the SHC1 bound to the phosphorylated homodimer of wild-type EGFR. Edited: Matthews, L, 2011-11-07 Reviewed: Greulich, H, 2011-11-15 Reviewed: Savas, S, 2011-11-15

ID

http://purl.obolibrary.org/obo/HINO_0009761

comment

Edited: Wu, G, 2011-11-07

Authored: Orlic-Milacic, M, 2011-11-04

Edited: D'Eustachio, P, 2011-11-07

Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphorylated dimers of EGFR cancer mutants has not been directly tested, but is assumed to happen in the same way it happens with the SHC1 bound to the phosphorylated homodimer of wild-type EGFR.

Edited: Matthews, L, 2011-11-07

Reviewed: Greulich, H, 2011-11-15

Reviewed: Savas, S, 2011-11-15

definition source

Pubmed8493579

Reactome, http://www.reactome.org

Pubmed15284455

has input

http://purl.obolibrary.org/obo/HINO_0011947

http://purl.obolibrary.org/obo/HINO_0012520

has output

http://purl.obolibrary.org/obo/HINO_0012518

label

Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex

prefixIRI

HINO:0009761

prefLabel

Phosphorylated SHC1 in complex with p-EGFR mutants recruits GRB2:SOS1 complex

seeAlso

Reactome Database ID Release 431225961

ReactomeREACT_115562

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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