loading...| Preferred Name | Amyloid precursor proteins form ordered fibrils | |
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Authored: Jupe, S, 2010-10-15 Amyloid fibril formation is associated with a wide range of diseases (Chiti & Dobson 2006), thoughthe accumulation and deposition of fibrillar material does not correlate well with disease pathogenesis and it is now widely believed that oligomeric amyloid forms are largely responsible for the cytotoxic effects of amyloid (Glabe 2009). Fibrils have been described as more like crystalline polymer structures than the protein monomers they are derived from (Wetzel et al. 2007). Fibril formation is usually preceded by the association of monomers into oligomeric structures (Kodali & Wetzel 2007). For Beta-amyloid, these are spherical structures with around 12 units (Bernstein et al. 2005). Larger structures called protofibrils are also observed, non-spherical filamentous structures lacking a periodic substructure (Goldsbury 2005). Reviewed: Perry, G, 2011-04-08 Edited: Jupe, S, 2011-04-08 |
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http://purl.obolibrary.org/obo/HINO_0009688 |
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Authored: Jupe, S, 2010-10-15 Amyloid fibril formation is associated with a wide range of diseases (Chiti & Dobson 2006), thoughthe accumulation and deposition of fibrillar material does not correlate well with disease pathogenesis and it is now widely believed that oligomeric amyloid forms are largely responsible for the cytotoxic effects of amyloid (Glabe 2009). Fibrils have been described as more like crystalline polymer structures than the protein monomers they are derived from (Wetzel et al. 2007). Fibril formation is usually preceded by the association of monomers into oligomeric structures (Kodali & Wetzel 2007). For Beta-amyloid, these are spherical structures with around 12 units (Bernstein et al. 2005). Larger structures called protofibrils are also observed, non-spherical filamentous structures lacking a periodic substructure (Goldsbury 2005). Reviewed: Perry, G, 2011-04-08 Edited: Jupe, S, 2011-04-08 |
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| definition source |
Pubmed18484335 Pubmed1270801 Pubmed279930 Pubmed9862427 Pubmed16095615 Pubmed9006323 Pubmed3053705 Pubmed3080684 Pubmed1837051 Pubmed18449172 Reactome, http://www.reactome.org Pubmed15962837 Pubmed8159701 Pubmed11401442 Pubmed15713083 Pubmed2195544 Pubmed8464497 Pubmed1849145 Pubmed10411933 Pubmed8097946 Pubmed3094007 Pubmed9054935 Pubmed16756495 Pubmed3142462 Pubmed17251001 Pubmed2900981 Pubmed8490014 Pubmed8870004 Pubmed11467836 Pubmed17198370 Pubmed2118650 Pubmed10391242 Pubmed3035556 |
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Amyloid precursor proteins form ordered fibrils |
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HINO:0009688 |
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Amyloid precursor proteins form ordered fibrils |
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Reactome Database ID Release 43977136 ReactomeREACT_75876 |
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