Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Id | http://purl.obolibrary.org/obo/HINO_0009684
http://purl.obolibrary.org/obo/HINO_0009684
|
|---|---|
| Preferred Name | Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody |
| Definitions |
Cetuximab binds to the extracellular domain of EGFR and blocks ligand binding, leading to receptor inactivation, internalization and degradation. Cetuximab is approved for combination therapy and monotherapy of metastatic colorectal cancer and advanced squamous cell carcinoma of head and neck in patients whose tumors over-express wild-type EGFR protein, usually due to amplification of EGFR gene.
Edited: Wu, G, 2011-11-07
Authored: Orlic-Milacic, M, 2011-11-04
Edited: D'Eustachio, P, 2011-11-07
Edited: Matthews, L, 2011-11-07
Reviewed: Greulich, H, 2011-11-15
Reviewed: Savas, S, 2011-11-15
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody
|
|---|---|
| comment |
Cetuximab binds to the extracellular domain of EGFR and blocks ligand binding, leading to receptor inactivation, internalization and degradation. Cetuximab is approved for combination therapy and monotherapy of metastatic colorectal cancer and advanced squamous cell carcinoma of head and neck in patients whose tumors over-express wild-type EGFR protein, usually due to amplification of EGFR gene.
Edited: Wu, G, 2011-11-07
Authored: Orlic-Milacic, M, 2011-11-04
Edited: D'Eustachio, P, 2011-11-07
Edited: Matthews, L, 2011-11-07
Reviewed: Greulich, H, 2011-11-15
Reviewed: Savas, S, 2011-11-15
See more
See less
|
| prefLabel |
Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody
|
| definition source |
Reactome, http://www.reactome.org
Pubmed16314626
Pubmed15837620
Pubmed15269313
|
| prefixIRI |
HINO:0009684
|
| seeAlso |
ReactomeREACT_115741
Reactome Database ID Release 431248677
|
| subClassOf | |
| type | |
| has input | |
| has output |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |