loading...| Preferred Name |
Stabilisation of RAF by further phosphorylation |
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| Definitions |
has a Stoichiometric coefficient of 2 Edited: Schmidt, EE, 0000-00-00 00:00:00 An unidentified protein tyrosine kinase located in the plasma membrane phosphorylates tyrosine residues at 340 and 341 (Y1, Y2 in diagram) of Raf-1. This serves to further stabilise the active 'open' Raf-1 conformation. While the kinase has not been definitively identified, Src is a plausible candidate: coexpression of Raf-1 and Src in Sf9 cells resulted in phosphorylation of Y340/Y341 and enzymatic activationof Raf-1; Raf-1 interacts with Src and co-immunoprecipitates with Src/Fyn in NIH-3T3 cells. Authored: Charalambous, M, 2005-01-07 11:17:43 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009580 |
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| comment |
has a Stoichiometric coefficient of 2 Edited: Schmidt, EE, 0000-00-00 00:00:00 An unidentified protein tyrosine kinase located in the plasma membrane phosphorylates tyrosine residues at 340 and 341 (Y1, Y2 in diagram) of Raf-1. This serves to further stabilise the active 'open' Raf-1 conformation. While the kinase has not been definitively identified, Src is a plausible candidate: coexpression of Raf-1 and Src in Sf9 cells resulted in phosphorylation of Y340/Y341 and enzymatic activationof Raf-1; Raf-1 interacts with Src and co-immunoprecipitates with Src/Fyn in NIH-3T3 cells. Authored: Charalambous, M, 2005-01-07 11:17:43 |
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| definition source |
Reactome, http://www.reactome.org Pubmed7692235 Pubmed7517401 Pubmed9069260 |
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| label |
Stabilisation of RAF by further phosphorylation |
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| prefixIRI |
HINO:0009580 |
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| prefLabel |
Stabilisation of RAF by further phosphorylation |
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| seeAlso |
ReactomeREACT_525 EC Number: 2.7.10 Reactome Database ID Release 43109829 |
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