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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009556
http://purl.obolibrary.org/obo/HINO_0009556
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|---|---|
| Preferred Name | AKT phosphorylates MDM2 |
| Definitions |
has a Stoichiometric coefficient of 2
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07
Reviewed: Greene, LA, 2007-11-08 15:39:37
AKT phosphorylates MDM2 on two serine residues, at positions 166 and 188 (Feng et al. 2004, Milne et al. 2004). AKT-mediated phosphorylation of ubiquitin-protein ligase E3 MDM2 promotes nuclear localization and inhibits interaction between MDM2 and p19ARF, thereby decreasing p53 stability. This leads to a decreased expression of p53 target genes, such as BAX, that promote apoptosis (Zhou et al. 2001).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
AKT phosphorylates MDM2
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| comment |
has a Stoichiometric coefficient of 2
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07
Reviewed: Greene, LA, 2007-11-08 15:39:37
AKT phosphorylates MDM2 on two serine residues, at positions 166 and 188 (Feng et al. 2004, Milne et al. 2004). AKT-mediated phosphorylation of ubiquitin-protein ligase E3 MDM2 promotes nuclear localization and inhibits interaction between MDM2 and p19ARF, thereby decreasing p53 stability. This leads to a decreased expression of p53 target genes, such as BAX, that promote apoptosis (Zhou et al. 2001).
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| prefLabel |
AKT phosphorylates MDM2
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| definition source |
Pubmed11715018
Reactome, http://www.reactome.org
Pubmed15527798
Pubmed15169778
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| prefixIRI |
HINO:0009556
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| seeAlso |
EC Number: 2.7.11
ReactomeREACT_12537
Reactome Database ID Release 43198599
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| subClassOf | |
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| has input | |
| has output |
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