loading...| Preferred Name | Binding of CBL to EGFR | |
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| Definitions |
has a Stoichiometric coefficient of 2 Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Phosphorylation at tyrosine Y1045 of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009516 |
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| comment |
has a Stoichiometric coefficient of 2 Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 Phosphorylation at tyrosine Y1045 of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor. |
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| definition source |
Reactome, http://www.reactome.org Pubmed15475003 |
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| label |
Binding of CBL to EGFR |
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| prefixIRI |
HINO:0009516 |
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| prefLabel |
Binding of CBL to EGFR |
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| seeAlso |
ReactomeREACT_12632 Reactome Database ID Release 43183055 |
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