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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009337
http://purl.obolibrary.org/obo/HINO_0009337
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|---|---|
| Preferred Name | Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation |
| Definitions |
has a Stoichiometric coefficient of 2
Edited: Shamovsky, V, 2011-08-12
Reviewed: Fitzgerald, Katherine A, 2012-11-13
Reviewed: Gillespie, ME, 2010-11-30
Authored: Shamovsky, V, 2010-06-01
The mechanism of TBK1 or IKKi{epsilon} activation by TICAM1 is unclear. It was suggested that these protein kinases undergo autophosphorylation. The most recent studies showed that phosphorylation and the activation of TBK1/ IKKi are catalyzed by a distinct protein kinase (Clark et al. 2009). Other studies demonstrated an essential role of TRAF3 in the activation of TBK1 (Hacker et al 2006).<p>It was also shown that the ubiquitin like domain (ULD) of TBK1 and IKK-i, a regulatory component, is involved in the control of kinase activation, substrate presentation and downstream signaling.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
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|---|---|
| comment |
has a Stoichiometric coefficient of 2
Edited: Shamovsky, V, 2011-08-12
Reviewed: Fitzgerald, Katherine A, 2012-11-13
Reviewed: Gillespie, ME, 2010-11-30
Authored: Shamovsky, V, 2010-06-01
The mechanism of TBK1 or IKKi{epsilon} activation by TICAM1 is unclear. It was suggested that these protein kinases undergo autophosphorylation. The most recent studies showed that phosphorylation and the activation of TBK1/ IKKi are catalyzed by a distinct protein kinase (Clark et al. 2009). Other studies demonstrated an essential role of TRAF3 in the activation of TBK1 (Hacker et al 2006).<p>It was also shown that the ubiquitin like domain (ULD) of TBK1 and IKK-i, a regulatory component, is involved in the control of kinase activation, substrate presentation and downstream signaling.
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| prefLabel |
Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
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| definition source |
Pubmed15210742
Pubmed17599067
Pubmed12692549
Reactome, http://www.reactome.org
Pubmed17047224
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| prefixIRI |
HINO:0009337
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| seeAlso |
Reactome Database ID Release 43936941
ReactomeREACT_25081
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| subClassOf | |
| type | |
| has input | |
| has output |
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