Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Id | http://purl.obolibrary.org/obo/HINO_0009319
http://purl.obolibrary.org/obo/HINO_0009319
|
|---|---|
| Preferred Name | TRIF:activated TLR3/TLR4 complex recruits RIP1 |
| Definitions |
has a Stoichiometric coefficient of 2
Edited: Shamovsky, V, 2011-08-12
Reviewed: Fitzgerald, Katherine A, 2012-11-13
Authored: de Bono, B, 2005-08-16 10:54:15
RIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to the TICAM1 [Cusson-Hermance N et al 2005]. Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins [Bertrand MJM et al 2011].<p> RIP3 was shown to inhibit TRIF-induced NF-kB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 [Meylan E et al 2004].
Reviewed: Gay, NJ, 2006-04-24 16:48:17
Reviewed: Gillespie, ME, 2010-11-30
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
TRIF:activated TLR3/TLR4 complex recruits RIP1
|
|---|---|
| comment |
has a Stoichiometric coefficient of 2
Edited: Shamovsky, V, 2011-08-12
Reviewed: Fitzgerald, Katherine A, 2012-11-13
Authored: de Bono, B, 2005-08-16 10:54:15
RIP1 is recruited to the activated TLR receptor by binding to TICAM1(TRIF) via its RHIM motif, followed by its polyubiquitination. Polyubiquitination is possibly mediated by TRAF6 that is also recruited to the TICAM1 [Cusson-Hermance N et al 2005]. Other E3-ubiquitin ligases - cIAP1 and cIAP2 - have been reported to promote polyubiquitination of RIP proteins [Bertrand MJM et al 2011].<p> RIP3 was shown to inhibit TRIF-induced NF-kB activation in dose-dependent manner when overexpressed in HEK293T cells by competing with TRIF to bind RIP1 [Meylan E et al 2004].
Reviewed: Gay, NJ, 2006-04-24 16:48:17
Reviewed: Gillespie, ME, 2010-11-30
See more
See less
|
| prefLabel |
TRIF:activated TLR3/TLR4 complex recruits RIP1
|
| definition source |
Pubmed21931591
Reactome, http://www.reactome.org
Pubmed16246838
Pubmed15814722
Pubmed16115877
Pubmed15064760
See more
See less
|
| prefixIRI |
HINO:0009319
|
| seeAlso |
ReactomeREACT_6713
Reactome Database ID Release 43168921
|
| subClassOf | |
| type | |
| has input | |
| has output |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |