loading...| Preferred Name | RIP3 binds TRIF to mediate necroptosis | |
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Reviewed: Fitzgerald, Katherine A, 2012-11-13 has a Stoichiometric coefficient of 4 Authored: Shamovsky, V, 2012-05-15 TLR3 and TLR4 -directed programmed necrosis (necroptosis) is mediated by the TRIF-RIP3 pathway in mouse macrophages [He S e al 2011]. RIP3 was shown to be essential mediator in TLR3-induced necroptotic cell death in human epithelial cell lines. Knockdown of RIP3 in human keratinocyte HaCaT cells blocked TLR3-mediated necroptosis without affecting the apoptotic response. Moreover, overexpression of RIP3 in human epithelial carcinoma cell line HeLa led to increased caspase-independent TLR3-induced cell death in the absence of IAPs [Feoktistova M et al 2011]. In addition, in caspase-8- or FADD-deficient human Jurkat cells dsRNA induced programmed necrosis, instead of apoptosis [Kalai M et al 2002]. Thus, when caspase-dependent apoptosis is inhibited or absent, the alternative RIP3-mediated programmed cell death is induced. Edited: Shamovsky, V, 2012-11-19 |
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http://purl.obolibrary.org/obo/HINO_0009313 |
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Reviewed: Fitzgerald, Katherine A, 2012-11-13 has a Stoichiometric coefficient of 4 Authored: Shamovsky, V, 2012-05-15 TLR3 and TLR4 -directed programmed necrosis (necroptosis) is mediated by the TRIF-RIP3 pathway in mouse macrophages [He S e al 2011]. RIP3 was shown to be essential mediator in TLR3-induced necroptotic cell death in human epithelial cell lines. Knockdown of RIP3 in human keratinocyte HaCaT cells blocked TLR3-mediated necroptosis without affecting the apoptotic response. Moreover, overexpression of RIP3 in human epithelial carcinoma cell line HeLa led to increased caspase-independent TLR3-induced cell death in the absence of IAPs [Feoktistova M et al 2011]. In addition, in caspase-8- or FADD-deficient human Jurkat cells dsRNA induced programmed necrosis, instead of apoptosis [Kalai M et al 2002]. Thus, when caspase-dependent apoptosis is inhibited or absent, the alternative RIP3-mediated programmed cell death is induced. Edited: Shamovsky, V, 2012-11-19 |
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Pubmed12181749 Pubmed22123964 Reactome, http://www.reactome.org Pubmed15814722 Pubmed21737330 |
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RIP3 binds TRIF to mediate necroptosis |
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HINO:0009313 |
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RIP3 binds TRIF to mediate necroptosis |
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ReactomeREACT_150365 GENE ONTOLOGYGO:0060555 Reactome Database ID Release 432569057 |
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