loading...| Preferred Name | TLR3/4-induced ripoptosome assembly | |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Authored: Shamovsky, V, 2012-05-15 TRIF was repored to efficiently induce apoptosis when overexpressed in human HEK293T cells. TRIF-induced apoptosis occurred through activation of the FADD-caspase-8 axis [Kaiser WJ and Offermann MK 2005; Kalai M et al 2002; Estornes Y et al 2012]. C-terminus of TRIF was shown to form complexes with both RIP1 and RIP3, and disruption of these interactions by mutating the RHIM eliminated the ability of TRIF to induce apoptosis [Kaiser WJ and Offermann MK 2005].<p> Prevention of RIP1 ubiquitination leads to a strong association of RIP1 and caspase-8 [Feoktistova M et al 2011, Tenev et al 2011]. Edited: Shamovsky, V, 2012-11-19 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009309 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Authored: Shamovsky, V, 2012-05-15 TRIF was repored to efficiently induce apoptosis when overexpressed in human HEK293T cells. TRIF-induced apoptosis occurred through activation of the FADD-caspase-8 axis [Kaiser WJ and Offermann MK 2005; Kalai M et al 2002; Estornes Y et al 2012]. C-terminus of TRIF was shown to form complexes with both RIP1 and RIP3, and disruption of these interactions by mutating the RHIM eliminated the ability of TRIF to induce apoptosis [Kaiser WJ and Offermann MK 2005]. Prevention of RIP1 ubiquitination leads to a strong association of RIP1 and caspase-8 [Feoktistova M et al 2011, Tenev et al 2011]. Edited: Shamovsky, V, 2012-11-19 |
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| definition source |
Pubmed12181749 Reactome, http://www.reactome.org Pubmed15814722 Pubmed12752666 Pubmed22421964 Pubmed21737330 Pubmed14739303 Pubmed21737329 |
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| has input |
http://purl.obolibrary.org/obo/UniProt_Q13158 |
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| label |
TLR3/4-induced ripoptosome assembly |
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| prefixIRI |
HINO:0009309 |
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| prefLabel |
TLR3/4-induced ripoptosome assembly |
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| seeAlso |
Reactome Database ID Release 432562541 ReactomeREACT_150447 |
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