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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009162
http://purl.obolibrary.org/obo/HINO_0009162
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|---|---|
| Preferred Name | MAL(TIRAP) binds PIP2-rich regions in the plasma membrane |
| Definitions |
Authored: Shamovsky, V, 2012-05-15
Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13
Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].
Edited: Shamovsky, V, 2012-11-19
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
MAL(TIRAP) binds PIP2-rich regions in the plasma membrane
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| comment |
Authored: Shamovsky, V, 2012-05-15
Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13
Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].
Edited: Shamovsky, V, 2012-11-19
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| prefLabel |
MAL(TIRAP) binds PIP2-rich regions in the plasma membrane
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| definition source |
Reactome, http://www.reactome.org
Pubmed19509286
Pubmed16751103
Pubmed15585605
Pubmed11544529
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| prefixIRI |
HINO:0009162
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| seeAlso |
ReactomeREACT_150399
Reactome Database ID Release 432559456
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| has input | |
| has output |
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