loading...| Preferred Name | IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex | |
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Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002]. Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 |
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http://purl.obolibrary.org/obo/HINO_0009152 |
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Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002]. Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 |
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Pubmed12297423 Pubmed20485341 Pubmed18829464 Reactome, http://www.reactome.org Pubmed19592493 Pubmed11960013 Pubmed19498957 |
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IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex |
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HINO:0009152 |
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IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex |
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ReactomeREACT_6975 Reactome Database ID Release 43166082 |
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