loading...| Preferred Name | Activated TLR2/4:MAL interacts with BTK | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase, which plays an essential role in B cell receptor (BCR) signaling [Brunner C et al 2005]. BTK has been also implicated in TLR signaling [Lee KG et al 2012, Jefferies CA et al 2003]. Interaction studies revealed that BTK can associate with intracellular TIR-domains of TLRs 4, 6, 8 and 9. Furthermore, BTK was found to interact with other proteins involved in TLR2/4 signaling - MyD88, MAL and IRAK-1 [Jefferies CA et al 2003]. Reviewed: Napetschnig, Johanna, 2012-11-16 Authored: Shamovsky, V, 2012-04-19 Edited: Shamovsky, V, 2012-11-06 Reviewed: D'Eustachio, P, 2012-05-25 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0009142 |
|
| comment |
has a Stoichiometric coefficient of 2 Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase, which plays an essential role in B cell receptor (BCR) signaling [Brunner C et al 2005]. BTK has been also implicated in TLR signaling [Lee KG et al 2012, Jefferies CA et al 2003]. Interaction studies revealed that BTK can associate with intracellular TIR-domains of TLRs 4, 6, 8 and 9. Furthermore, BTK was found to interact with other proteins involved in TLR2/4 signaling - MyD88, MAL and IRAK-1 [Jefferies CA et al 2003]. Reviewed: Napetschnig, Johanna, 2012-11-16 Authored: Shamovsky, V, 2012-04-19 Edited: Shamovsky, V, 2012-11-06 Reviewed: D'Eustachio, P, 2012-05-25 |
|
| definition source |
Reactome, http://www.reactome.org Pubmed12724322 Pubmed15944945 Pubmed22454496 |
|
| has input | ||
| has output | ||
| label |
Activated TLR2/4:MAL interacts with BTK |
|
| prefixIRI |
HINO:0009142 |
|
| prefLabel |
Activated TLR2/4:MAL interacts with BTK |
|
| seeAlso |
ReactomeREACT_150418 Reactome Database ID Release 432559414 |
|
| subClassOf |