Authored: Shamovsky, V, 2012-05-15 CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been identified as a co-receptor that interacts with LPS. CD14 has been also implicated in TLR-2 signalling [Hajishengallis G et al 2006; Zivkovic A et al 2011]. Studies have demonstrated that CD14 can bind to triacylated lipoproteins and mediate the activation of the innate immune system trough TLR2:TLR1 complex [Nakata T et al 2006; Manukyan M et al 2005; Triantafilou M et al 2006] Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13 Edited: Shamovsky, V, 2012-11-19

http://purl.obolibrary.org/obo/HINO_0009131

Authored: Shamovsky, V, 2012-05-15

CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been identified as a co-receptor that interacts with LPS. CD14 has been also implicated in TLR-2 signalling [Hajishengallis G et al 2006; Zivkovic A et al 2011]. Studies have demonstrated that CD14 can bind to triacylated lipoproteins and mediate the activation of the innate immune system trough TLR2:TLR1 complex [Nakata T et al 2006; Manukyan M et al 2005; Triantafilou M et al 2006]

Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13

Edited: Shamovsky, V, 2012-11-19

Pubmed15714590

Reactome, http://www.reactome.org

Pubmed16880211

http://purl.obolibrary.org/obo/UniProt_P08571

http://purl.obolibrary.org/obo/HINO_0012859

http://purl.obolibrary.org/obo/HINO_0005966

TLR1/2 ligand binds to CD14

HINO:0009131

TLR1/2 ligand binds to CD14

ReactomeREACT_150261

Reactome Database ID Release 432559468

http://purl.obolibrary.org/obo/INO_0000040