loading...| Preferred Name | TRAF6 binds to hp- IRAK1 | |
| Synonyms |
|
|
| Definitions |
Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002). Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0009126 |
|
| comment |
Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002). Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 |
|
| definition source |
Pubmed8837778 Pubmed12140561 Pubmed18070982 Reactome, http://www.reactome.org Pubmed11287640 Pubmed12138165 |
|
| has input | ||
| has output | ||
| label |
TRAF6 binds to hp- IRAK1 |
|
| prefixIRI |
HINO:0009126 |
|
| prefLabel |
TRAF6 binds to hp- IRAK1 |
|
| seeAlso |
Reactome Database ID Release 43166363 ReactomeREACT_6856 |
|
| subClassOf |