loading...| Preferred Name | First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal | |
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Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1. |
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http://purl.obolibrary.org/obo/HINO_0009125 |
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| comment |
Authored: de Bono, B, 2005-08-16 10:54:15 Reviewed: Gay, NJ, 2006-04-24 16:48:17 has a Stoichiometric coefficient of 4 Reviewed: Napetschnig, Johanna, 2012-11-16 Edited: Shamovsky, V, 2012-11-06 Reviewed: Gillespie, ME, 2010-11-30 First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1. |
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| definition source |
Reactome, http://www.reactome.org Pubmed14625308 Pubmed11960013 |
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| label |
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal |
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| prefixIRI |
HINO:0009125 |
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First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal |
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Reactome Database ID Release 43166119 ReactomeREACT_6833 EC Number: 2.7.11 |
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