loading...| Preferred Name |
GRB2:SOS1 is recruited to activated FGFR through p-SHC1 |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway. |
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http://purl.obolibrary.org/obo/HINO_0008992 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Phosphorylated SHC1 links FGFR to Grb2 (Klint et al. 1995) leading to the formation of a signaling complex including Shc, Grb2 and Sos. Transformation of NIH 3T3 cells with v-Src produced a strong constitutive association of FGFR1 with Shc, Grb2 and Sos (Curto et al. 1998) suggesting Src involvement. Recruitment of Grb2-Sos links FGFR to the Ras pathway. |
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| definition source |
Reactome, http://www.reactome.org Pubmed9045692 Pubmed7559490 Pubmed9480847 |
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| label |
GRB2:SOS1 is recruited to activated FGFR through p-SHC1 |
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| prefixIRI |
HINO:0008992 |
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| prefLabel |
GRB2:SOS1 is recruited to activated FGFR through p-SHC1 |
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| seeAlso |
ReactomeREACT_111149 Reactome Database ID Release 431268258 |
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