Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Autophosphorylation of IRE1 dimer

Synonyms
Definitions

has a Stoichiometric coefficient of 2 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Dimerization of the N-terminal luminal regions of IRE1-alpha brings the cytosolic C-terminal regions in proximity. The C-terminal region possesses kinase activity and the homodimer trans-autophosphorylates. From homology with Saccharomyces IRE1-alpha the phosphorylation of human IRE1-alpha is believed to be at Ser724. Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49

ID

http://purl.obolibrary.org/obo/HINO_0008878

comment

has a Stoichiometric coefficient of 2

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

Reviewed: Urano, F, 2010-04-30

Dimerization of the N-terminal luminal regions of IRE1-alpha brings the cytosolic C-terminal regions in proximity. The C-terminal region possesses kinase activity and the homodimer trans-autophosphorylates. From homology with Saccharomyces IRE1-alpha the phosphorylation of human IRE1-alpha is believed to be at Ser724.

Authored: May, B, 2009-06-02 00:51:49

Edited: May, B, 2009-06-02 00:51:49

definition source

Pubmed9637683

Pubmed16973740

Reactome, http://www.reactome.org

Pubmed11069889

has input

http://purl.obolibrary.org/obo/HINO_0017500

http://purl.obolibrary.org/obo/CHEBI_15422

has output

http://purl.obolibrary.org/obo/HINO_0017501

http://purl.obolibrary.org/obo/CHEBI_16761

label

Autophosphorylation of IRE1 dimer

prefixIRI

HINO:0008878

prefLabel

Autophosphorylation of IRE1 dimer

seeAlso

Reactome Database ID Release 43381091

EC Number: 2.7.11

ReactomeREACT_18399

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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