Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Preferred Name

Cleavage of ATF6-alpha by S2P
Synonyms
Definitions

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S2P catalyzes the second of these, cleaving the ATF6-alpha S1P cleavage product within its transmembrane domain. This cleavage liberates a 50 kD N-terminal fragment with bZIP transcription factor activity into the cytosol. Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49
ID

http://purl.obolibrary.org/obo/HINO_0008876
comment

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

Reviewed: Urano, F, 2010-04-30

Once in the Golgi, ATF6-alpha undergoes two sequential proteolytic cleavages. S2P catalyzes the second of these, cleaving the ATF6-alpha S1P cleavage product within its transmembrane domain. This cleavage liberates a 50 kD N-terminal fragment with bZIP transcription factor activity into the cytosol.

Authored: May, B, 2009-06-02 00:51:49

Edited: May, B, 2009-06-02 00:51:49
definition source

Reactome, http://www.reactome.org

Pubmed15299016

Pubmed11163209

Pubmed10564271
has input

http://purl.obolibrary.org/obo/UniProt_P18850
has output

http://purl.obolibrary.org/obo/UniProt_P18850
label

Cleavage of ATF6-alpha by S2P
prefixIRI

HINO:0008876
prefLabel

Cleavage of ATF6-alpha by S2P
seeAlso

Reactome Database ID Release 43420818

ReactomeREACT_18387
subClassOf

http://purl.obolibrary.org/obo/INO_0000040
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