Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA

Synonyms
Definitions

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Phosphorylated IRE1-alpha homodimers with bound ADP have endoribonuclease activity in their C-terminal (cytosolic) regions. The IRE1-alpha homodimers cleave an internal 26 nucleotide segment out of the Xbp-1 mRNA. In yeast the resulting RNAs are ligated by a tRNA ligase but the corresponding human ligase has not been identified. The cleavage and ligation leads to a frameshift in the Xbp-1 mRNA which results in a longer ORF that encodes Xbp-1 (S), the active form of the Xbp-1 transcription factor Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-03 Edited: May, B, 2009-06-03

ID

http://purl.obolibrary.org/obo/HINO_0008873

comment

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

Phosphorylated IRE1-alpha homodimers with bound ADP have endoribonuclease activity in their C-terminal (cytosolic) regions. The IRE1-alpha homodimers cleave an internal 26 nucleotide segment out of the Xbp-1 mRNA. In yeast the resulting RNAs are ligated by a tRNA ligase but the corresponding human ligase has not been identified. The cleavage and ligation leads to a frameshift in the Xbp-1 mRNA which results in a longer ORF that encodes Xbp-1 (S), the active form of the Xbp-1 transcription factor

Reviewed: Urano, F, 2010-04-30

Authored: May, B, 2009-06-03

Edited: May, B, 2009-06-03

definition source

Reactome, http://www.reactome.org

Pubmed19622636

Pubmed11779464

Pubmed18242182

Pubmed17026957

has input

http://purl.obolibrary.org/obo/HINO_0025383

has output

http://purl.obolibrary.org/obo/HINO_0025381

label

Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA

prefixIRI

HINO:0008873

prefLabel

Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA

seeAlso

Reactome Database ID Release 43425923

ReactomeREACT_22313

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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