Preferred Name |
Translation and translocation of XBP1(S) to the Nucleus |
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Definitions |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Phosphorylated IRE1-alpha homodimers with bound ADP have endoribonuclease activity in their C-terminal (cytosolic) regions. In particular, the homodimers cleave an internal 26 nucleotide segment out of the Xbp-1 mRNA. In yeast the resulting RNAs are ligated by a tRNA ligase but the corresponding human enzyme has not been identified. The cleavage and ligation leads to a frameshift which results in a longer ORF that encodes Xbp-1 (S), the active form of the Xbp-1 transcription factor.<br>The ribonuclease activity of IRE1-alpha also degrades subsets of mRNAs in the vicinity of the ER membrane, thereby reducing the amount of protein entering the ER.<br>Xbp-1 mRNA that has been cleaved by IRE1-alpha encodes a 40 kd protein designated Xbp-1 (S). Xbp-1 (S) is a potent bZIP transcription factor that transits from the cytosol to the nucleus and binds the sequence CCACG in the ER Stress Responsive Element (ERSE). Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
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ID |
http://purl.obolibrary.org/obo/HINO_0008872 |
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comment |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Phosphorylated IRE1-alpha homodimers with bound ADP have endoribonuclease activity in their C-terminal (cytosolic) regions. In particular, the homodimers cleave an internal 26 nucleotide segment out of the Xbp-1 mRNA. In yeast the resulting RNAs are ligated by a tRNA ligase but the corresponding human enzyme has not been identified. The cleavage and ligation leads to a frameshift which results in a longer ORF that encodes Xbp-1 (S), the active form of the Xbp-1 transcription factor. Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
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definition source |
Pubmed16461360 Reactome, http://www.reactome.org Pubmed11779464 Pubmed8657566 |
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has output | ||
label |
Translation and translocation of XBP1(S) to the Nucleus |
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prefixIRI |
HINO:0008872 |
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prefLabel |
Translation and translocation of XBP1(S) to the Nucleus |
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seeAlso |
ReactomeREACT_18336 Reactome Database ID Release 43381203 |
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subClassOf |