loading...| Preferred Name |
Dissociation of PERK:BiP Heterodimer |
|
| Synonyms |
|
|
| Definitions |
PERK is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER. Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008871 |
|
| comment |
PERK is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER. Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
|
| definition source |
Reactome, http://www.reactome.org Pubmed17956313 Pubmed11907036 |
|
| has input | ||
| has output | ||
| label |
Dissociation of PERK:BiP Heterodimer |
|
| prefixIRI |
HINO:0008871 |
|
| prefLabel |
Dissociation of PERK:BiP Heterodimer |
|
| seeAlso |
ReactomeREACT_18413 Reactome Database ID Release 43381086 |
|
| subClassOf |