loading...| Preferred Name |
FGFR2b binds to FGF |
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| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 2 Authored: de Bono, B, 2007-01-10 10:27:18 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008792 |
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| comment |
has a Stoichiometric coefficient of 2 Authored: de Bono, B, 2007-01-10 10:27:18 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets. |
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| definition source |
Pubmed16597617 Reactome, http://www.reactome.org Pubmed1697263 Pubmed15863029 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0024940 |
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| has output | ||
| label |
FGFR2b binds to FGF |
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| prefixIRI |
HINO:0008792 |
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| prefLabel |
FGFR2b binds to FGF |
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| seeAlso |
Reactome Database ID Release 43190260 ReactomeREACT_9462 |
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| subClassOf |