loading...| Preferred Name |
FGFR1 fusions bind PLCgamma |
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| Synonyms |
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| Definitions |
FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Guasch, 2001; Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1 and ZMYM2-FGFR1, mutation of the PLCgamma binding site significantly decreased the transformative phenotype of the FGFR1 fusion (Roumiantsev, 2004). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008624 |
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| comment |
FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Guasch, 2001; Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1 and ZMYM2-FGFR1, mutation of the PLCgamma binding site significantly decreased the transformative phenotype of the FGFR1 fusion (Roumiantsev, 2004). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed17698633 Pubmed15050920 Reactome, http://www.reactome.org Pubmed11689702 Pubmed18412956 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0004755 |
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| has output | ||
| label |
FGFR1 fusions bind PLCgamma |
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| prefixIRI |
HINO:0008624 |
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| prefLabel |
FGFR1 fusions bind PLCgamma |
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| seeAlso |
Reactome Database ID Release 431839094 ReactomeREACT_121275 |
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| subClassOf |