loading...| Preferred Name |
Ligand-independent dimerization of overexpressed FGFR1 |
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| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 2 FGFR1-amplified lung cancer and breast cancer cells show strong phosphorylation of FGFR1 and do not show elevated levels of FGF ligand, suggesting that these receptors can undergo ligand-independent activation. Phosphorylation is enhanced in the presence of exogenous ligand, supporting the notion that overexpressed FGFR1 can be activated by both ligand- and ligand-independent pathways (Koziczak, 2004; Dutt, 2008; Weiss, 2010). The biochemical consequences of overexpression of FGFR1 in other cancer types remain to be determined (reviewed in Turner and Gross, 2010; Wesche, 2011. Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008585 |
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| comment |
has a Stoichiometric coefficient of 2 FGFR1-amplified lung cancer and breast cancer cells show strong phosphorylation of FGFR1 and do not show elevated levels of FGF ligand, suggesting that these receptors can undergo ligand-independent activation. Phosphorylation is enhanced in the presence of exogenous ligand, supporting the notion that overexpressed FGFR1 can be activated by both ligand- and ligand-independent pathways (Koziczak, 2004; Dutt, 2008; Weiss, 2010). The biochemical consequences of overexpression of FGFR1 in other cancer types remain to be determined (reviewed in Turner and Gross, 2010; Wesche, 2011. Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed15116089 Reactome, http://www.reactome.org Pubmed21711248 Pubmed20094046 Pubmed21160078 Pubmed21666749 |
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| label |
Ligand-independent dimerization of overexpressed FGFR1 |
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| prefixIRI |
HINO:0008585 |
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| prefLabel |
Ligand-independent dimerization of overexpressed FGFR1 |
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| seeAlso |
ReactomeREACT_121098 Reactome Database ID Release 431982065 |
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