loading...| Preferred Name |
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers |
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| Definitions |
has a Stoichiometric coefficient of 2 Treatment of FGFR1-amplified lung and breast cancer cell lines with the in vitro reagents PD173704, SU5402 and FIIN-1 inhibits proliferation, while cells expressing wild-type levels of FGFR1 are insensitive to inhibitors, suggesting that amplified FGFR1 may be a suitable therapeutic target in some cancer lines (Weiss, 2010; Reis-Filho, 2006; Dutt, 2011; Turner, 2010). In fact, a number of other small molecule inhibitors, including Dovitinib and AZD4547, are currently in clinical trials for treatment of FGFR1-amplified cancers (reviewed in Turner and Grose, 2010; Wesche, 2011; http://ClinicalTrials.gov) Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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http://purl.obolibrary.org/obo/HINO_0008581 |
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| comment |
has a Stoichiometric coefficient of 2 Treatment of FGFR1-amplified lung and breast cancer cell lines with the in vitro reagents PD173704, SU5402 and FIIN-1 inhibits proliferation, while cells expressing wild-type levels of FGFR1 are insensitive to inhibitors, suggesting that amplified FGFR1 may be a suitable therapeutic target in some cancer lines (Weiss, 2010; Reis-Filho, 2006; Dutt, 2011; Turner, 2010). In fact, a number of other small molecule inhibitors, including Dovitinib and AZD4547, are currently in clinical trials for treatment of FGFR1-amplified cancers (reviewed in Turner and Grose, 2010; Wesche, 2011; http://ClinicalTrials.gov) Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed20179196 Pubmed21711248 Pubmed20094046 Pubmed17121884 Pubmed21160078 Pubmed21666749 |
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Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers |
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| prefixIRI |
HINO:0008581 |
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| prefLabel |
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers |
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| seeAlso |
Reactome Database ID Release 432023462 ReactomeREACT_121386 |
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