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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | TXNIP binds NLRP3 | |
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| Definitions |
Authored: Jupe, S, 2011-04-28 Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome. Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008529 |
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| comment |
Authored: Jupe, S, 2011-04-28 Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome. Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06
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| definition source |
Pubmed20023662 Reactome, http://www.reactome.org
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| label |
TXNIP binds NLRP3
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| prefixIRI |
HINO:0008529
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| prefLabel |
TXNIP binds NLRP3
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| seeAlso |
ReactomeREACT_75932 Reactome Database ID Release 431250272
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