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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | ROS oxidize thioredoxin | |
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| Definitions |
Authored: Jupe, S, 2011-04-28 The presence of reactive oxygen species (ROS) leads to the oxidation of thioredoxin and consequent release of TXNIP (Zhou et al. 2010). The source of the ROS is unclear but they are known to be essential for caspase-1 activation (Cruz et al. 2007) and are produced in response to all known NLRP3 activators (Dostert et al. 2008, Zhou et al. 2010). The freed TXNIP binds NLRP3 and is proposed to activate the NLRP3 inflammasome, explaining how ROS can bring about NLRP3 activation. Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008525 |
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| comment |
Authored: Jupe, S, 2011-04-28 The presence of reactive oxygen species (ROS) leads to the oxidation of thioredoxin and consequent release of TXNIP (Zhou et al. 2010). The source of the ROS is unclear but they are known to be essential for caspase-1 activation (Cruz et al. 2007) and are produced in response to all known NLRP3 activators (Dostert et al. 2008, Zhou et al. 2010). The freed TXNIP binds NLRP3 and is proposed to activate the NLRP3 inflammasome, explaining how ROS can bring about NLRP3 activation. Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06
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| definition source |
Pubmed20023662 Pubmed17132626 Reactome, http://www.reactome.org Pubmed18403674
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ROS oxidize thioredoxin
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| prefixIRI |
HINO:0008525
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| prefLabel |
ROS oxidize thioredoxin
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| seeAlso |
ReactomeREACT_75816 Reactome Database ID Release 431250280
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