Link to this page
Human Interaction Network Ontology
| Preferred Name | Activated NOD2 oligomerizes | |
| Synonyms |
|
|
| Definitions |
Authored: Jupe, S, 2010-04-22 NOD2 is activated by MDP in a LRR domain dependent manner. Based on studies of NOD1 activation and structural data from the NLR-related scaffold Apaf-1, the LRR domain is believed to have a negative influence on NOD2 self-association (Inohara et al. 2000, Riedl & Salvesen 2007); binding of MDP is believed to cause conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on these observations, NOD2 is generally believed to form hexamers or heptamers (Martinon & Tschopp, 2005). NOD2 oliogomerization has been observed in NOD2-transfected HEK293T cells (Zhao et al. 2007). Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 has a Stoichiometric coefficient of 6 Reviewed: Rittinger, K, 2011-06-06 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008454 |
|
| comment |
Authored: Jupe, S, 2010-04-22 NOD2 is activated by MDP in a LRR domain dependent manner. Based on studies of NOD1 activation and structural data from the NLR-related scaffold Apaf-1, the LRR domain is believed to have a negative influence on NOD2 self-association (Inohara et al. 2000, Riedl & Salvesen 2007); binding of MDP is believed to cause conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on these observations, NOD2 is generally believed to form hexamers or heptamers (Martinon & Tschopp, 2005). NOD2 oliogomerization has been observed in NOD2-transfected HEK293T cells (Zhao et al. 2007). Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 has a Stoichiometric coefficient of 6 Reviewed: Rittinger, K, 2011-06-06
|
|
| definition source |
Reactome, http://www.reactome.org Pubmed10880512 Pubmed17377525 Pubmed15967716 Pubmed17303577
|
|
| has input | ||
| has output | ||
| label |
Activated NOD2 oligomerizes
|
|
| prefixIRI |
HINO:0008454
|
|
| prefLabel |
Activated NOD2 oligomerizes
|
|
| seeAlso |
ReactomeREACT_75789 Reactome Database ID Release 43708349
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |