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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0008453
http://purl.obolibrary.org/obo/HINO_0008453
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|---|---|
| Preferred Name | Activated NOD1 oligomerizes |
| Definitions |
Authored: Jupe, S, 2010-04-22
NOD1 is activated by iE-DAP in a LRR domain dependent manner. The LRR domain has a negative influence on NOD1 self-association (Inohara et al. 2000); binding of iE-DAP likely causes conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on this observation, NOD1 and NOD2 are believed to form oligomers of this size (Martinon & Tschopp, 2005).
Edited: Jupe, S, 2011-04-28
Reviewed: Wong, Edmond, 2011-06-06
Reviewed: Kufer, TA, 2011-04-28
has a Stoichiometric coefficient of 6
Reviewed: Rittinger, K, 2011-06-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Activated NOD1 oligomerizes
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| comment |
Authored: Jupe, S, 2010-04-22
NOD1 is activated by iE-DAP in a LRR domain dependent manner. The LRR domain has a negative influence on NOD1 self-association (Inohara et al. 2000); binding of iE-DAP likely causes conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on this observation, NOD1 and NOD2 are believed to form oligomers of this size (Martinon & Tschopp, 2005).
Edited: Jupe, S, 2011-04-28
Reviewed: Wong, Edmond, 2011-06-06
Reviewed: Kufer, TA, 2011-04-28
has a Stoichiometric coefficient of 6
Reviewed: Rittinger, K, 2011-06-06
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| prefLabel |
Activated NOD1 oligomerizes
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| definition source |
Reactome, http://www.reactome.org
Pubmed10880512
Pubmed15967716
Pubmed10329646
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| prefixIRI |
HINO:0008453
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| seeAlso |
ReactomeREACT_75809
Reactome Database ID Release 43622310
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| subClassOf | |
| type | |
| has input | |
| has output |
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