loading...| Preferred Name | iE-DAP elicits a NOD1 response | |
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| Definitions |
Early studies suggested that NOD1 and NOD2 responded to lipopolysaccharides (LPS), but this was later shown to be due to contamination of LPS with bacterial peptidoglycans (PGNs), the true elicitor for NODs. It is generally believed that PGNs bind NOD1 though this remains to be formally demonstrated. NOD1 senses PGN moieties with a minimal dipeptide structure of D-gamma-glutamyl-meso-diaminopimelic acid (iE-DAP), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus. Attachment of acyl residues enhances NOD1 stimulation several hundred fold, possibly by facilitating PGN entry into the cell (Hasegawa et al. 2007). Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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http://purl.obolibrary.org/obo/HINO_0008447 |
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Early studies suggested that NOD1 and NOD2 responded to lipopolysaccharides (LPS), but this was later shown to be due to contamination of LPS with bacterial peptidoglycans (PGNs), the true elicitor for NODs. It is generally believed that PGNs bind NOD1 though this remains to be formally demonstrated. NOD1 senses PGN moieties with a minimal dipeptide structure of D-gamma-glutamyl-meso-diaminopimelic acid (iE-DAP), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus. Attachment of acyl residues enhances NOD1 stimulation several hundred fold, possibly by facilitating PGN entry into the cell (Hasegawa et al. 2007). Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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| definition source |
Pubmed12791997 Pubmed12796777 Reactome, http://www.reactome.org Pubmed17322292 |
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iE-DAP elicits a NOD1 response |
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HINO:0008447 |
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iE-DAP elicits a NOD1 response |
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Reactome Database ID Release 43168400 ReactomeREACT_75907 |
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