loading...| Preferred Name | NOD1 induced apoptosis is mediated by RIP2 and CARD8 | |
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Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 NOD1 was found to coimmunoprecipitate with several procaspases containing long prodomains with CARDs or DEDs, including caspase-1, caspase-2, caspase-4, caspase-8, and caspase-9, but not those with short prodomains like caspase-3 or caspase-7. Deletions of caspase-9 determined that the CARD domain was required for this interaction (Inohara et al. 1999). More recently, NOD1 activation of apoptosis was shown to require the RIP2-dependent activation of caspase-8, this effect being inhibited by CASP8 and FADD-like apoptosis regulator, also called FLICE-inhibitory protein, FLIP or CLARP (da Silva Correia et al. 2007), which is a specific inhibitor of caspase-8 (Irmler et al. 1997). Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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http://purl.obolibrary.org/obo/HINO_0008444 |
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Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Reviewed: Wong, Edmond, 2011-06-06 NOD1 was found to coimmunoprecipitate with several procaspases containing long prodomains with CARDs or DEDs, including caspase-1, caspase-2, caspase-4, caspase-8, and caspase-9, but not those with short prodomains like caspase-3 or caspase-7. Deletions of caspase-9 determined that the CARD domain was required for this interaction (Inohara et al. 1999). More recently, NOD1 activation of apoptosis was shown to require the RIP2-dependent activation of caspase-8, this effect being inhibited by CASP8 and FADD-like apoptosis regulator, also called FLICE-inhibitory protein, FLIP or CLARP (da Silva Correia et al. 2007), which is a specific inhibitor of caspase-8 (Irmler et al. 1997). Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
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Pubmed9217161 Reactome, http://www.reactome.org Pubmed17186025 Pubmed10329646 |
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NOD1 induced apoptosis is mediated by RIP2 and CARD8 |
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HINO:0008444 |
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NOD1 induced apoptosis is mediated by RIP2 and CARD8 |
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Reactome Database ID Release 43622420 ReactomeREACT_75921 |
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