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Human Interaction Network Ontology
| Preferred Name | TAK1 phosphorylates MKK6 | |
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| Definitions |
has a Stoichiometric coefficient of 2 Authored: Ray, KP, 2010-05-17 Reviewed: Wong, Edmond, 2011-06-06 Within the TAK1 complex (TAK1 plus TAB1 and TAB2/3) activated TAK1 phosphorylates IKKB, MAPK kinase 6 (MKK6) and other MAPKs to activate the NFkappaB and MAPK signaling pathways. TAB2 within the TAK1 complex can be linked to polyubiquitinated TRAF6; current models of IL-1 signaling suggest that the TAK1 complex is linked to TRAF6, itself complexed with polyubiquitinated IRAK1 which is linked via NEMO to the IKK complex. The TAK1 complex is also essential for NOD signaling; NOD receptors bind RIP2 which recruits the TAK1 complex (Hasegawa et al. 2008). Reviewed: Kufer, TA, 2011-04-28 Edited: Jupe, S, 2010-05-17 Reviewed: Rittinger, K, 2011-06-06 |
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http://purl.obolibrary.org/obo/HINO_0008443 |
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has a Stoichiometric coefficient of 2 Authored: Ray, KP, 2010-05-17 Reviewed: Wong, Edmond, 2011-06-06 Within the TAK1 complex (TAK1 plus TAB1 and TAB2/3) activated TAK1 phosphorylates IKKB, MAPK kinase 6 (MKK6) and other MAPKs to activate the NFkappaB and MAPK signaling pathways. TAB2 within the TAK1 complex can be linked to polyubiquitinated TRAF6; current models of IL-1 signaling suggest that the TAK1 complex is linked to TRAF6, itself complexed with polyubiquitinated IRAK1 which is linked via NEMO to the IKK complex. The TAK1 complex is also essential for NOD signaling; NOD receptors bind RIP2 which recruits the TAK1 complex (Hasegawa et al. 2008). Reviewed: Kufer, TA, 2011-04-28 Edited: Jupe, S, 2010-05-17 Reviewed: Rittinger, K, 2011-06-06
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| definition source |
Pubmed11460167 Pubmed18079694 Reactome, http://www.reactome.org
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| label |
TAK1 phosphorylates MKK6
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| prefixIRI |
HINO:0008443
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| prefLabel |
TAK1 phosphorylates MKK6
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| seeAlso |
ReactomeREACT_22190 EC Number: 2.7.11.25 Reactome Database ID Release 43727819
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