loading...| Preferred Name | Activation of p38 MAPK | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 8 p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3. Edited: Jupe, S, 2011-04-28 Authored: Jupe, S, 2011-04-08 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008442 |
|
| comment |
has a Stoichiometric coefficient of 8 p38 MAPK has 4 representative isoforms in humans, p38 alpha (Han et al. 1993), p38-beta (Jiang et al. 1996), p38-gamma (Lechner et al. 1996) and p38-delta (Hu et al. 1999). All are activated by phosphorylation on a canonical TxY motif by the dual-specificity kinase MKK6, which displays minimal substrate selectivity amongst the p38 isoforms (Zarubin & Han, 2005). p38 alpha and gamma are also activated by MKK3. Edited: Jupe, S, 2011-04-28 Authored: Jupe, S, 2011-04-08 Reviewed: Wong, Edmond, 2011-06-06 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 |
|
| definition source |
Pubmed15686620 Reactome, http://www.reactome.org Pubmed9430721 Pubmed7693711 Pubmed10066767 Pubmed8663524 Pubmed8633070 |
|
| has input | ||
| has output | ||
| label |
Activation of p38 MAPK |
|
| prefixIRI |
HINO:0008442 |
|
| prefLabel |
Activation of p38 MAPK |
|
| seeAlso |
Reactome Database ID Release 431247960 ReactomeREACT_75807 |
|
| subClassOf |