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Human Interaction Network Ontology
| Preferred Name | dsRNA binds to RIG-I | |
| Synonyms |
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| Definitions |
has a Stoichiometric coefficient of 2 Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 RIG-I has two copies of caspase recruitment domain (CARD) in its N-terminus, DExD/H helicase domain with an ATP binding motif in the middle and a repressor domain (RD) in the C-terminus. In the absence of appropriate stimulation, RIG-I is in a 'closed' conformation in which the repressor domain phyically interacts with the helicase domain masking CARD. Upon viral infection the free triphosphate structure at the 5' end of the viral RNAs activate RIG-I by binding to its RNA helicase domain. This provokes change in RIG-I conformation exposing the CARD leading to RIG-I dimerization and allowing it to interact with the mitochondria-bound interferon beta promoter stimulator-1 (IPS-1). Authored: Garapati, P V, 2010-08-02 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008406 |
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| comment |
has a Stoichiometric coefficient of 2 Reviewed: Kawai, T, Akira, S, 2010-10-30 Edited: Garapati, P V, 2010-08-02 RIG-I has two copies of caspase recruitment domain (CARD) in its N-terminus, DExD/H helicase domain with an ATP binding motif in the middle and a repressor domain (RD) in the C-terminus. In the absence of appropriate stimulation, RIG-I is in a 'closed' conformation in which the repressor domain phyically interacts with the helicase domain masking CARD. Upon viral infection the free triphosphate structure at the 5' end of the viral RNAs activate RIG-I by binding to its RNA helicase domain. This provokes change in RIG-I conformation exposing the CARD leading to RIG-I dimerization and allowing it to interact with the mitochondria-bound interferon beta promoter stimulator-1 (IPS-1). Authored: Garapati, P V, 2010-08-02
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| definition source |
Reactome, http://www.reactome.org Pubmed18591409 Pubmed15208624
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| has input |
http://purl.obolibrary.org/obo/HINO_0005075 |
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| has output | ||
| label |
dsRNA binds to RIG-I
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| prefixIRI |
HINO:0008406
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| prefLabel |
dsRNA binds to RIG-I
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| seeAlso |
ReactomeREACT_25357 Reactome Database ID Release 43168935
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