loading...| Preferred Name | AGER binds ERK1/2 | |
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| Definitions |
Binding of ligand to AGER results in the activation of multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade (Lander et al. 1997), cdc42/Rac (Huttunen et al. 1999), and activation of NF-?B (Tanaka et al. 2000). A membrane-proximal cytoplasmic region of the advanced glycation end-products receptor (AGER) is responsible for binding to extracellular signal-regulated protein kinase-1 and -2 (ERK1/2 or MAPK3/1). This region is similar to the D-domain, an ERK docking site which is conserved in some ERK substrates (Ishihara et al. 2003). Edited: Jupe, S, 2010-11-16 Reviewed: Yan, SD, 2010-11-09 Authored: Jupe, S, 2010-06-01 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008404 |
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| comment |
Binding of ligand to AGER results in the activation of multiple signaling pathways, including the mitogen-activated protein kinase (MAPK) cascade (Lander et al. 1997), cdc42/Rac (Huttunen et al. 1999), and activation of NF-?B (Tanaka et al. 2000). A membrane-proximal cytoplasmic region of the advanced glycation end-products receptor (AGER) is responsible for binding to extracellular signal-regulated protein kinase-1 and -2 (ERK1/2 or MAPK3/1). This region is similar to the D-domain, an ERK docking site which is conserved in some ERK substrates (Ishihara et al. 2003). Edited: Jupe, S, 2010-11-16 Reviewed: Yan, SD, 2010-11-09 Authored: Jupe, S, 2010-06-01 |
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| definition source |
Pubmed12935895 Pubmed10391939 Reactome, http://www.reactome.org Pubmed10829018 Pubmed9211935 |
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| label |
AGER binds ERK1/2 |
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| prefixIRI |
HINO:0008404 |
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| prefLabel |
AGER binds ERK1/2 |
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| seeAlso |
Reactome Database ID Release 43879362 ReactomeREACT_25020 |
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