Activated FGFR mutants bind PLC-gamma

Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established. Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15

http://purl.obolibrary.org/obo/HINO_0008185

Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established.

Edited: Rothfels, K, 2012-05-16

Authored: Rothfels, K, 2012-02-09

Reviewed: Ezzat, S, 2012-05-15

Pubmed16091734

Pubmed16844695

Pubmed19749790

Pubmed19147536

Pubmed10652257

Pubmed18337450

Reactome, http://www.reactome.org

Pubmed10918587

http://purl.obolibrary.org/obo/HINO_0004824

http://purl.obolibrary.org/obo/CHEBI_16618

http://purl.obolibrary.org/obo/UniProt_P19174

http://purl.obolibrary.org/obo/HINO_0023659

Activated FGFR mutants bind PLC-gamma

HINO:0008185

Activated FGFR mutants bind PLC-gamma

Reactome Database ID Release 432077380

ReactomeREACT_121127

http://purl.obolibrary.org/obo/INO_0000040