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FGFR mutants phosphorylate FRS2alpha |
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| Definitions |
After recruitment to activated FGFR mutants, FRS2alpha is believed to be phosphorylated, potentially on all 6 of the tyrosines phosphorylated by wild-type FGFRs. Phosphorylation of FRS2alpha by FGFR has been demonstrated in some cases (see for instance Qing, 2009; Bai, 2010; Ahmed, 2008; Raffioni, 1998) and is inferred to occur in others based on activation of downstream signaling modules (reviewed in Wesche, 2011; Turner and Grose, 2010). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 6 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008172 |
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| comment |
After recruitment to activated FGFR mutants, FRS2alpha is believed to be phosphorylated, potentially on all 6 of the tyrosines phosphorylated by wild-type FGFRs. Phosphorylation of FRS2alpha by FGFR has been demonstrated in some cases (see for instance Qing, 2009; Bai, 2010; Ahmed, 2008; Raffioni, 1998) and is inferred to occur in others based on activation of downstream signaling modules (reviewed in Wesche, 2011; Turner and Grose, 2010). Edited: Rothfels, K, 2012-05-16 Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 6 |
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| definition source |
Pubmed17505008 Pubmed19381019 Reactome, http://www.reactome.org Pubmed20709759 Pubmed21711248 Pubmed20094046 Pubmed9857065 Pubmed21666749 Pubmed18373495 |
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FGFR mutants phosphorylate FRS2alpha |
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| prefixIRI |
HINO:0008172 |
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| prefLabel |
FGFR mutants phosphorylate FRS2alpha |
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| seeAlso |
ReactomeREACT_120797 EC Number: 2.7.10 Reactome Database ID Release 431982077 |
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